monoclonal gammopathy

noun

plural monoclonal gammopathies

: any of various disorders marked by proliferation of a single, abnormal clone of a plasma cell or B cell especially in the bone marrow resulting in an abnormal increase of monoclonal antibody in the blood serum and urine and that include both benign or asymptomatic conditions and neoplastic conditions (such as multiple myeloma)

Word History

First Known Use

1966, in the meaning defined above

Medical Definition

monoclonal gammopathy

noun

: any of various disorders marked by proliferation of a single clone of antibody-producing lymphoid cells resulting in an abnormal increase of a monoclonal antibody in the blood serum and urine and that include both benign or asymptomatic conditions and neoplastic conditions (as multiple myeloma and Waldenström's macroglobulinemia)

called also plasma cell dyscrasia

see m protein sense 2